Article
Generation of recombinant lymphocytic choriomeningitis viruses with trisegmented genomes stably expressing two additional genes of interest.
Proceedings of the National Academy of Sciences of the United States of America - 3 Mar 2009
Emonet Sebastien F, Garidou Lucile, McGavern Dorian B, de la Torre Juan C
Abstract excerpt
Several arenaviruses cause hemorrhagic fever disease in humans for which no licensed vaccines are available and current therapeutic intervention is limited to the off-label use of the wide-spectrum antiviral ribavirin. However, the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) has proven to be a Rosetta stone for the investigation of virus-host interactions. Arenaviruses have a bisegmented...
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