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Arenavirus Genome Rearrangement for the Development of Live Attenuated Vaccines

14 May 2015

Abstract excerpt

UNLABELLED: Several members of the Arenaviridae family cause hemorrhagic fever disease in humans and pose serious public health problems in their geographic regions of endemicity as well as a credible biodefense threat. To date, there have been no FDA-approved arenavirus vaccines, and current antiarenaviral therapy is limited to an off-label use of ribavirin that is only partially effective. Arenaviruses are...

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PMID: 25972555
DOI: 10.1128/jvi.00307-15

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