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Article

Insulin-like growth factor-1 endues monocytes with immune suppressive ability to inhibit inflammation in the intestine.

Scientific reports - 15 Jan 2015

Ge Rong-Ti, Mo Li-Hua, Wu Ruijin, Liu Jiang-Qi, Zhang Huan-Ping, Liu Zhigang, Liu Zhanju, Yang Ping-Chang

Abstract excerpt

The pathogenesis of some chronic inflammation such as inflammatory bowel disease is unclear. Insulin-like growth factor-1 (IGF1) has active immune regulatory capability. This study aims to investigate into the mechanism by which IGF1 modulates the monocyte (Mo) properties to inhibit immune inflammation in the intestine. In this study, the production of IGF1 by intestinal epithelial cells was evaluated by real...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25588622
DOI: 10.1038/srep07735
PMCID: PMC4295102

Genes

IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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