Article
Pre-treatment with IL-1β enhances the efficacy of MSC transplantation in DSS-induced colitis.
Cellular & molecular immunology - 1 Nov 2012
Fan Hongye, Zhao Guangfeng, Liu Liu, Liu Fei, Gong Wei, Liu Xianqin, Yang Liu, Wang Jianjun, Hou Yayi
Abstract excerpt
Mesenchymal stem cells (MSCs) have been used experimentally for treating inflammatory disorders, partly due to their immunosuppressive properties. Although interleukin-1β (IL-1β) is one of the most important inflammatory mediators, growing evidence indicates that IL-1β signaling elicits the immunosuppressive properties of MSCs. However, it remains unclear how IL-1β signaling accomplishes this activity. Here, we...
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