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The small regulatory RNA FasX enhances group A S treptococcus virulence and inhibits pilus expression via serotype‐specific targets

14 Jan 2015

Abstract excerpt

Bacterial pathogens commonly show intra-species variation in virulence factor expression and often this correlates with pathogenic potential. The group A Streptococcus (GAS) produces a small regulatory RNA (sRNA), FasX, which regulates the expression of pili and the thrombolytic agent streptokinase. As GAS serotypes are polymorphic regarding (a) FasX abundance, (b) the fibronectin, collagen, T-antigen (FCT)...

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PMID: 25586884
DOI: 10.1111/mmi.12935

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