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Article

Global epithelial cell transcriptional responses reveal Streptococcus pyogenes Fas regulator activity association with bacterial aggressiveness.

Cellular microbiology - 1 Sept 2005

Klenk Michael, Koczan Dirk, Guthke Reinhard, Nakata Masanobu, Thiesen Hans-Jürgen, Podbielski Andreas, Kreikemeyer Bernd

Abstract excerpt

The bacterial human pathogen Streptococcus pyogenes (group A streptococci, GAS) is able to adhere to, internalize into and cross-talk on multiple levels with its host cells. To gain insight into the Fas function in pathogenesis we used Affymetrix human genome DNA-arrays to measure temporal and global transcriptional responses of HEp-2 cells infected with M49 S. pyogenes wild-type bacteria and DeltafasX, an...

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PMID: 16098212
DOI: 10.1111/j.1462-5822.2005.00548.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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