The group A <i>Streptococcus</i> small regulatory RNA FasX enhances streptokinase activity by increasing the stability of the <i>ska</i> mRNA transcript

Abstract excerpt

Small RNA molecules play key regulatory roles in many bacterial species. However, little mechanistic data exists for the action of small regulatory RNAs in the human pathogen group A Streptococcus (GAS). Here, we analysed the relationship between a putative GAS sRNA and production of the secreted virulence factor streptokinase (SKA). SKA promotes GAS dissemination by activating conversion of host plasminogen into...

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