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Article

Streptococcus pyogenes malate degradation pathway links pH regulation and virulence.

Infection and immunity - 1 Mar 2015

Paluscio Elyse, Caparon Michael G

Abstract excerpt

The ability of Streptococcus pyogenes to infect different niches within its human host most likely relies on its ability to utilize alternative carbon sources. In examining this question, we discovered that all sequenced S. pyogenes strains possess the genes for the malic enzyme (ME) pathway, which allows malate to be used as a supplemental carbon source for growth. ME is comprised of four genes in two adjacent...

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Identifiers

PMID: 25583521
DOI: 10.1128/IAI.02814-14
PMCID: PMC4333477

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PTS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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