Molecular subtypes of clear cell renal cell carcinoma are associated with sunitinib response in the metastatic setting.

doi:10.1158/1078-0432.CCR-14-1128

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Molecular subtypes of clear cell renal cell carcinoma are associated with sunitinib response in the metastatic setting.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2015

Beuselinck Benoit, Job Sylvie, Becht Etienne, Karadimou Alexandra, Verkarre Virginie, Couchy Gabrielle, Giraldo Nicolas, Rioux-Leclercq Nathalie, Molinié Vincent, Sibony Mathilde, Elaidi Reza, Teghom Corinne, Patard Jean-Jacques, Méjean Arnaud, Fridman Wolf Herman, Sautès-Fridman Catherine, de Reyniès Aurélien, Oudard Stéphane, Zucman-Rossi Jessica

Abstract excerpt

PURPOSE: Selecting patients with metastatic clear-cell renal cell carcinoma (m-ccRCC) who might benefit from treatment with targeted tyrosine kinase inhibitors (TKI) is a challenge. Our aim was to identify molecular markers associated with outcome in patients with m-ccRCC treated with sunitinib. EXPERIMENTAL DESIGN: We performed global transcriptome analyses on 53 primary resected ccRCC tumors from patients who...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis Inhibitors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Renal Cell

Share to Disease-Free Survival

Share to Indoles

Share to Kidney Neoplasms

Share to Pyrroles

Share to Sunitinib

Share to Vascular Endothelial Growth Factor Receptor-2

Source

Open in PubMed

Identifiers

PMID: 25583177
DOI: 10.1158/1078-0432.CCR-14-1128

Genes

PBRM1
PDCD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular subtypes of clear cell renal cell carcinoma are associated with sunitinib response in the metastatic setting.PMID 25583177Read ↗

Genomic Profiling and Molecular Characterization of Clear Cell Renal Cell Carcinoma.Semantic proximity Read ↗

Transcriptomic characterization and innovative molecular classification of clear cell renal cell carcinoma in the Chinese populationSemantic proximity Read ↗

Transcriptomic Profiling of the Tumor Microenvironment Reveals Distinct Subgroups of Clear Cell Renal Cell Cancer: Data from a Randomized Phase III TrialSemantic proximity Read ↗

Multi-omics comprehensive analysis of renal clear cell carcinoma to distinguish subtypes with different molecular characterizations and therapeutic strategiesSemantic proximity Read ↗

Whole genome sequencing refines stratification and therapy of patients with clear cell renal cell carcinomaSemantic proximity Read ↗

Solute carrier-related signature for assessing prognosis and immunity in patients with clear-cell renal cell carcinomaSemantic proximity Read ↗

Integrated genomic analysis identifies subclasses and prognosis signatures of kidney cancer.Semantic proximity Read ↗

Silencing of genes by promoter hypermethylation shapes tumor microenvironment and resistance to immunotherapy in clear-cell renal cell carcinomasSemantic proximity Read ↗

Identification of clear cell renal cell carcinoma subtypes by integrating radiomics and transcriptomicsSemantic proximity Read ↗

Whole genome sequencing refines stratification and therapy of patients with clear cell renal cell carcinoma.Semantic proximity Read ↗

Tumor microenvironment immune subtypes for classification of novel clear cell renal cell carcinoma profiles with prognostic and therapeutic implications.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.