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Article

The translocator protein gene is associated with symptom severity and cerebral pain processing in fibromyalgia.

Brain, behavior, and immunity - 1 Nov 2016

Kosek Eva, Martinsen Sofia, Gerdle Björn, Mannerkorpi Kaisa, Löfgren Monika, Bileviciute-Ljungar Indre, Fransson Peter, Schalling Martin, Ingvar Martin, Ernberg Malin, Jensen Karin B

Abstract excerpt

The translocator protein (TSPO) is upregulated during glia activation in chronic pain patients. TSPO constitutes the rate-limiting step in neurosteroid synthesis, thus modulating synaptic transmission. Related serotonergic mechanisms influence if pro- or anti-nociceptive neurosteroids are produced. This study investigated the effects of a functional genetic polymorphism regulating the binding affinity to the...

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Source

Identifiers

PMID: 27448744
DOI: 10.1016/j.bbi.2016.07.150

Genes

TSPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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