Article
Mitochondrial Genetics in Cardiovascular Health and Disease: A Scientific Statement From the American Heart Association.
Circulation - 3 Feb 2026
Fetterman Jessica L, Chinnery Patrick F, McClellan Rebecca, Wallace Douglas C, Suomalainen Anu, Ojala Tiina, Lewis Samantha C, Ballinger Scott W
Abstract excerpt
Metabolic and genetic abnormalities have long been noted in cardiovascular diseases, but the contribution of mitochondrial genetic (mitochondrial DNA [mtDNA]) variation is understudied. Mitochondrial genetics is complex in that each mitochondrion contains multiple mtDNA copies that may carry different variants, which is called heteroplasmy. Heteroplasmic variation is dynamic, increases with advancing age, and may...
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