Article
Networks of Dynamic Allostery Regulate Enzyme Function.
Structure (London, England : 1993) - 7 Feb 2017
Holliday Michael Joseph, Camilloni Carlo, Armstrong Geoffrey Stuart, Vendruscolo Michele, Eisenmesser Elan Zohar
Abstract excerpt
Many protein systems rely on coupled dynamic networks to allosterically regulate function. However, the broad conformational space sampled by non-coherently dynamic systems has precluded detailed analysis of their communication mechanisms. Here, we have developed a methodology that combines the high sensitivity afforded by nuclear magnetic resonance relaxation techniques and single-site multiple mutations, termed...
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