Analysis of B-cell subpopulations in monoclonal gammopathies.

doi:10.1016/j.clml.2014.12.003

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Article

Analysis of B-cell subpopulations in monoclonal gammopathies.

Clinical lymphoma, myeloma & leukemia - 1 Apr 2015

Všianská Pavla, Říhová Lucie, Varmužová Tamara, Suská Renata, Kryukov Fedor, Mikulášová Aneta, Kupská Renata, Penka Miroslav, Pour Luděk, Adam Zdeněk, Hájek Roman

Abstract excerpt

BACKGROUND: Multiple myeloma (MM) is characterized by accumulation of pathological plasma cells (PCs) in bone marrow (BM) as a result of deregulation of B-cell development. To clarify its pathophysiology it is necessary to investigate in detail the developmental stages of B-cells. MATERIALS AND METHODS: Enumeration of total CD19-positive (CD19(+)) cells and their subpopulations together with PCs was done in...

Topics

Adult
Aged
Aged, 80 and over
Antigens, Surface
B-Lymphocyte Subsets
Chromosome Aberrations
Diagnosis, Differential
Female
Flow Cytometry
Humans
Immunophenotyping

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Monoclonal Gammopathy of Undetermined Significance

Multiple Myeloma

Paraproteinemias

Phenotype

Source

Open in PubMed

Identifiers

PMID: 25578543
DOI: 10.1016/j.clml.2014.12.003

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