Article
Analysis of B-cell subpopulations in monoclonal gammopathies.
Clinical lymphoma, myeloma & leukemia - 1 Apr 2015
Všianská Pavla, Říhová Lucie, Varmužová Tamara, Suská Renata, Kryukov Fedor, Mikulášová Aneta, Kupská Renata, Penka Miroslav, Pour Luděk, Adam Zdeněk, Hájek Roman
Abstract excerpt
BACKGROUND: Multiple myeloma (MM) is characterized by accumulation of pathological plasma cells (PCs) in bone marrow (BM) as a result of deregulation of B-cell development. To clarify its pathophysiology it is necessary to investigate in detail the developmental stages of B-cells. MATERIALS AND METHODS: Enumeration of total CD19-positive (CD19(+)) cells and their subpopulations together with PCs was done in...
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