Article
Flow cytometry detection of CD138 expression continuum between monotypic B and plasma cells is associated with both high IgM peak levels and MYD88 mutation and contributes to diagnosis of Waldenström macroglobulinemia.
Cytometry. Part B, Clinical cytometry - 1 Jan 2022
Gayet Mylene, Leymarie Vincent, Derouault Paco, Guérin Estelle, Vaidié Julien, Pascal Virginie, Boulin Mélanie, Dmytruk Nataliya, Chauzeix Jasmine, Trimoreau Franck, Gachard Nathalie, Feuillard Jean, Rizzo David
Abstract excerpt
BACKGROUND: Differential diagnosis of Waldenström macroglobulinemia (WM) with other indolent B-cell malignancies is still a challenge. Here, we propose an original and simple analysis of routine flow cytometry (FCM) unraveling the characteristic ongoing plasma cell (PC) differentiation of WM tumor B-cells. METHODS: FCM analysis of both B-cells and PC was performed on a series of 77 patients with IgM peak. MYD88...
Topics
- Flow Cytometry
- Humans
- Immunoglobulin M
- Mutation
- Myeloid Differentiation Factor 88
- Plasma Cells
- Syndecan-1
- Waldenstrom Macroglobulinemia