Article
Mutation profiling of tumor DNA from plasma and tumor tissue of colorectal cancer patients with a novel, high-sensitivity multiplexed mutation detection platform.
Oncotarget - 10 Feb 2015
Kidess Evelyn, Heirich Kyra, Wiggin Matthew, Vysotskaia Valentina, Visser Brendan C, Marziali Andre, Wiedenmann Bertram, Norton Jeffrey A, Lee Mark, Jeffrey Stefanie S, Poultsides George A
Abstract excerpt
BACKGROUND: Circulating tumor DNA (ctDNA) holds promise as a non-invasive means for tumor monitoring in solid malignancies. Assays with high sensitivity and multiplexed analysis of mutations are needed to enable broad application. METHODS: We developed a new assay based on sequence-specific synchronous coefficient of drag alteration (SCODA) technology, which enriches for mutant DNA to achieve high sensitivity and...
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