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Article

Trained immunity: consequences for the heterologous effects of BCG vaccination

1 Jan 2015

Abstract excerpt

A growing body of evidence from epidemiologic and immunologic studies have shown that in addition to target disease-specific effects, vaccines have heterologous effects towards unrelated pathogens. Like some other vaccines, bacille Calmette-Guerin (BCG) has shown in observational studies and randomized clinical trials to increase survival beyond the disease burden of the target disease. The immunologic substrate...

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PMID: 25573107
DOI: 10.1093/trstmh/tru168

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