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Aerosol vaccination with Bacille Calmette-Guerin induces a trained innate immune phenotype in calves

22 Feb 2019

Abstract excerpt

Mycobacterium bovis Bacillus Calmette-Guérin (BCG) is a live attenuated vaccine for use against tuberculosis (TB); however, it is known to reduce childhood mortality from infections other than TB. The unspecific protection induced by BCG vaccination has been associated with the induction of memory-like traits of the innate immune system identified as 'trained' immunity. In humans and mouse models, in vitro and in...

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PMID: 30794653
DOI: 10.1371/journal.pone.0212751

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