Article

BCG Vaccination Induces Trained Innate Immunity in Adults Over 50 Years of Age: A Randomized Trial in Guinea-Bissau

2020-06-18

Abstract excerpt

Bacillus Calmette-Guérin (BCG) has beneficial effects on overall morbidity and mortality in children and young adults. These effects have been linked to a heterologous increase of pro-inflammatory cytokine production by innate immune cells. It is unknown if BCG induces similar responses in older individuals. In Guinea-Bissau, we randomized 40 adults over 50 years of age to BCG-Japan or placebo. Two months after va...

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Literature Corpus work: ba6ead38-d8cf-5b98-99d9-089bbbd2f59a
DOI: 10.2139/ssrn.3611329

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