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The sodium-glucose cotransporter isoform 1 (SGLT-1) is important for sperm energetics, motility, and fertility

14 Apr 2022

Abstract excerpt

Glucose is a key substrate for supporting sperm energy production and function. Previous studies have demonstrated that sperm glucose uptake is facilitated by several isoforms of the glucose transporters (GLUT). Here, we report that sperm also expresses the Na+-dependent sodium glucose cotransporter (SGLT). This was first suggested by our observation that genetic deletion of the testis-specific Na,K-ATPase α4,...

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PMID: 35420639
DOI: 10.1093/biolre/ioac052

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