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Article

Vpu antagonizes BST-2-mediated restriction of HIV-1 release via beta-TrCP and endo-lysosomal trafficking.

PLoS pathogens - 1 May 2009

Mitchell Richard S, Katsura Chris, Skasko Mark A, Fitzpatrick Katie, Lau David, Ruiz Autumn, Stephens Edward B, Margottin-Goguet Florence, Benarous Richard, Guatelli John C

Abstract excerpt

The interferon-induced transmembrane protein BST-2/CD317 (tetherin) restricts the release of diverse enveloped viruses from infected cells. The HIV-1 accessory protein Vpu antagonizes this restriction by an unknown mechanism that likely involves the down-regulation of BST-2 from the cell surface. Here, we show that the optimal removal of BST-2 from the plasma membrane by Vpu requires the cellular protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19478868
DOI: 10.1371/journal.ppat.1000450
PMCID: PMC2679223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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