Article
A conservative mutant of a proteolytic fragment produced during fibril formation enhances fibrillogenesis.
Prion - 1 Jan 2014
Egorov Vladimir V, Lebedev Dmitry V, Shaldzhyan Aram A, Sirotkin Alexey K, Gorshkov Andrey N, Mirgorodskaya Olga A, Grudinina Natalia A, Vasin Andrey V, Shavlovsky Michael M
Abstract excerpt
The fibrillogenesis of a peptide corresponding to residues 35-51 of human α-lactalbumin (¹GYDTQAIVENNESTEYG¹⁷) can be dramatically enhanced by the addition of a tetrapeptide TDYG homologous to its C-terminus (TEYG). Generation of spontaneous hydrolytic products similar to this peptide was demonstrated by mass-spectrometry analysis of GYDTQAIVENNESTEYG peptide solution components during fibrillogenesis. Possible...
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