Article
The soluble cytoplasmic tail of CD45 (ct-CD45) in human plasma contributes to keep T cells in a quiescent state.
European journal of immunology - 1 Jan 2017
Puck Alexander, Hopf Stefan, Modak Madhura, Majdic Otto, Cejka Petra, Blüml Stephan, Schmetterer Klaus, Arnold-Schrauf Catharina, Gerwien Jens G, Frederiksen Klaus S, Thell Elisabeth, Leitner Judith, Steinberger Peter, Aigner Regina, Seyerl-Jiresch Maria, Zlabinger Gerhard J, Stöckl Johannes
Abstract excerpt
The cytoplasmic tail of CD45 (ct-CD45) is proteolytically cleaved and released upon activation of human phagocytes. It acts on T cells as an inhibitory, cytokine-like factor in vitro. Here, we show that ct-CD45 is abundant in human peripheral blood plasma from healthy adults compared with plasma derived from umbilical cord blood and plasma from patients with rheumatoid arthritis or systemic lupus erythematosus....
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