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Article

Imbalanced gp130 signalling in ApoE-deficient mice protects against atherosclerosis.

Atherosclerosis - 1 Feb 2015

Jones Gareth W, McLeod Louise, Kennedy Catherine L, Bozinovski Steven, Najdovska Meri, Jenkins Brendan J

Abstract excerpt

OBJECTIVE: Interleukin (IL)-6 is a key modulator of the acute phase response (APR), and while both are implicated in atherosclerosis, the pathological role of specific IL-6 signalling cascades is ill-defined. Since IL-6 employs the cytokine receptor gp130 to primarily activate the STAT3 pathway, here we evaluate whether gp130-dependent STAT3 activation modulates atherosclerosis. METHODS: High-fat diet-induced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytokine Receptor gp130

Share to Diet, High-Fat

Share to Plaque, Atherosclerotic

Share to Serum Amyloid A Protein

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Source

Identifiers

PMID: 25545330
DOI: 10.1016/j.atherosclerosis.2014.12.037

Genes

STAT3

Provenance

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