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Article

Clonal persistence and evolution during a decade of recurrent melanoma.

The Journal of investigative dermatology - 1 Jun 2006

Wang Ena, Voiculescu Sonia, Le Poole Isabelle C, El-Gamil Mona, Li Xin, Sabatino Marianna, Robbins Paul F, Nickoloff Brian J, Marincola Francesco M

Abstract excerpt

A patient with metastatic cutaneous melanoma responsive to immunotherapy experienced several recurrences over a decade of observation. With each recurrence, biopsies were obtained and cell lines generated. A rare mutation of the beta-catenin gene and an unbalanced methylation of the androgen receptor were documented in all cell lines. Karyotyping and comparative genomic hybridization identified consistent genetic...

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Identifiers

PMID: 16470173
DOI: 10.1038/sj.jid.5700193

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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