Article
Functional cloning of recurrence-specific antigens identifies molecular targets to treat tumor relapse.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Aug 2013
Boisgerault Nicolas, Kottke Timothy, Pulido Jose, Thompson Jill, Diaz Rosa Maria, Rommelfanger-Konkol Diana, Embry Addie, Saenz Dyana, Poeschla Eric, Pandha Hardev, Harrington Kevin, Melcher Alan, Selby Peter, Vile Richard
Abstract excerpt
Aggressive regrowth of recurrent tumors following treatment-induced dormancy represents a major clinical challenge for treatment of malignant disease. We reported previously that recurrent prostate tumors, which underwent complete macroscopic regression followed by aggressive regrowth, could be cured with a vesicular stomatitis virus (VSV)-expressed cDNA library derived from recurrent tumor cells. By screening...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.