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Article

p53 mutations change phosphatidylinositol acyl chain composition.

Cell reports - 6 Jan 2015

Naguib Adam, Bencze Gyula, Engle Dannielle D, Chio Iok I C, Herzka Tali, Watrud Kaitlin, Bencze Szilvia, Tuveson David A, Pappin Darryl J, Trotman Lloyd C

Abstract excerpt

Phosphatidylinositol phosphate (PIP) second messengers relay extracellular growth cues through the phosphorylation status of the inositol sugar, a signal transduction system that is deregulated in cancer. In stark contrast to PIP inositol head-group phosphorylation, changes in phosphatidylinositol (PI) lipid acyl chains in cancer have remained ill-defined. Here, we apply a mass-spectrometry-based method capable...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25543136
DOI: 10.1016/j.celrep.2014.12.010
PMCID: PMC4287966

Genes

PIP
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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