Article
Neuregulin 1 expression is a predictive biomarker for response to AV-203, an ERBB3 inhibitory antibody, in human tumor models.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2015
Meetze Kristan, Vincent Sylvie, Tyler Steven, Mazsa Elizabeth K, Delpero Andrea R, Bottega Steve, McIntosh Donna, Nicoletti Richard, Winston William M, Weiler Solly, Feng Bin, Gyuris Jeno, Weng Zhigang
Abstract excerpt
PURPOSE: ERBB3 is overexpressed in a broad spectrum of human cancers, and its aberrant activation is associated with tumor pathogenesis and therapeutic resistance to various anticancer agents. Neuregulin 1 (NRG1) is the predominant ligand for ERBB3 and can promote the heterodimerization of ERBB3 with other ERBB family members, resulting in activation of multiple intracellular signaling pathways. AV-203 is a...
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