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Article

Advances in Targeting HER3 as an Anticancer Therapy

7 Nov 2012

Abstract excerpt

HER3 (ErbB3) is a unique member of the human epidermal growth factor receptor (EGFR) family (ErbB family). It functions only through dimerization with other members of the ErbB family and modulates activity and sensitivity to targeted cancer therapies. This paper briefly describes the mechanism of HER3 in signal transduction and its potential role in acquired resistance to EGFR- and HER2-targeted therapies. We...

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Identifiers

PMID: 23198146
DOI: 10.1155/2012/817304

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