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Article

Inhibition of miR-34b and miR-34c enhances α-synuclein expression in Parkinson's disease.

FEBS letters - 30 Jan 2015

Kabaria Savan, Choi Doo Chul, Chaudhuri Amrita Datta, Mouradian M Maral, Junn Eunsung

Abstract excerpt

Mounting evidence suggests that microRNA (miR) dysregulation contributes to neurodegenerative disorders including Parkinson's disease (PD). MiR-34b and miR-34c have been previously shown to be down-regulated in the brains of patients with PD. Here, we demonstrate that miR-34b and miR-34c repress the expression of α-synuclein (α-syn), a key protein in PD pathogenesis. Inhibition of miR-34b and miR-34c expression...

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Identifiers

PMID: 25541488
DOI: 10.1016/j.febslet.2014.12.014
PMCID: PMC4306645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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