Article
WNT activation by lithium abrogates TP53 mutation associated radiation resistance in medulloblastoma.
Acta neuropathologica communications - 24 Dec 2014
Zhukova Nataliya, Ramaswamy Vijay, Remke Marc, Martin Dianna C, Castelo-Branco Pedro, Zhang Cindy H, Fraser Michael, Tse Ken, Poon Raymond, Shih David J H, Baskin Berivan, Ray Peter N, Bouffet Eric, Dirks Peter, von Bueren Andre O, Pfaff Elke, Korshunov Andrey, Jones David T W, Northcott Paul A, Kool Marcel, Pugh Trevor J, Pomeroy Scott L, Cho Yoon-Jae, Pietsch Torsten, Gessi Marco, Rutkowski Stefan, Bognár Laszlo, Cho Byung-Kyu, Eberhart Charles G, Conter Cecile Faure, Fouladi Maryam, French Pim J, Grajkowska Wieslawa A, Gupta Nalin, Hauser Peter, Jabado Nada, Vasiljevic Alexandre, Jung Shin, Kim Seung-Ki, Klekner Almos, Kumabe Toshihiro, Lach Boleslaw, Leonard Jeffrey R, Liau Linda M, Massimi Luca, Pollack Ian F, Ra Young Shin, Rubin Joshua B, Van Meir Erwin G, Wang Kyu-Chang, Weiss William A, Zitterbart Karel, Bristow Robert G, Alman Benjamin, Hawkins Cynthia E, Malkin David, Clifford Steven C, Pfister Stefan M, Taylor Michael D, Tabori Uri
Abstract excerpt
TP53 mutations confer subgroup specific poor survival for children with medulloblastoma. We hypothesized that WNT activation which is associated with improved survival for such children abrogates TP53 related radioresistance and can be used to sensitize TP53 mutant tumors for radiation. We examined the subgroup-specific role of TP53 mutations in a cohort of 314 patients treated with radiation. TP53 wild-type or...
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