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Article

Genetic alterations of TP53 and OTX2 indicate increased risk of relapse in WNT medulloblastomas.

Acta neuropathologica - 1 Dec 2022

Goschzik Tobias, Mynarek Martin, Doerner Evelyn, Schenk Alina, Spier Isabel, Warmuth-Metz Monika, Bison Brigitte, Obrecht Denise, Struve Nina, Kortmann Rolf-Dieter, Schmid Matthias, Aretz Stefan, Rutkowski Stefan, Pietsch Torsten

Abstract excerpt

This study aimed to re-evaluate the prognostic impact of TP53 mutations and to identify specific chromosomal aberrations as possible prognostic markers in WNT-activated medulloblastoma (WNT-MB). In a cohort of 191 patients with WNT-MBs, mutations in CTNNB1, APC, and TP53 were analyzed by DNA sequencing. Chromosomal copy-number aberrations were assessed by molecular inversion probe technology (MIP), SNP6, or 850k...

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Identifiers

PMID: 36181537
DOI: 10.1007/s00401-022-02505-5
PMCID: PMC9637613

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