Article
Chromosome 16q22 variants in a region associated with cardiovascular phenotypes correlate with ZFHX3 expression in a transcript-specific manner.
BMC genetics - 24 Dec 2014
Martin Ruairidh I R, Owens W Andrew, Cunnington Michael S, Mayosi Bongani M, Koref Mauro Santibáñez, Keavney Bernard D
Abstract excerpt
BACKGROUND: The ZFHX3 gene, located in Chromosome 16q22.3, codes for a transcription factor which is widely expressed in human tissues. Genome-wide studies have identified associations between variants within the gene and Kawasaki disease and atrial fibrillation. ZFHX3 has two main transcripts that utilise different transcription start sites. We examined the association between genetic variants in the 16q22.3...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.