Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Wild-type and specific mutant androgen receptor mediates transcription via 17β-estradiol in sex hormone-sensitive cancer cells.

Journal of cellular physiology - 1 Jul 2015

Susa Takao, Ikaga Reina, Kajitani Takashi, Iizuka Masayoshi, Okinaga Hiroko, Tamamori-Adachi Mimi, Okazaki Tomoki

Abstract excerpt

We previously encountered regulatory processes wherein dihydrotestosterone (DHT) exerted its inhibitory effect on parathyroid hormone-related protein (PTHrP) gene repression through the estrogen receptor (ER)α, but not the androgen receptor (AR), in breast cancer MCF-7 cells. Here, we investigated whether such aberrant ligand-nuclear receptor (NR) interaction is present in prostate cancer LNCaP cells. First, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Dihydrotestosterone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estradiol

Share to Estrogen Receptor alpha

Share to Gene Expression Regulation, Neoplastic

Share to Parathyroid Hormone-Related Protein

Share to Prostatic Neoplasms

Share to Receptors, Androgen

Source

Open in PubMed Open full text

Identifiers

PMID: 25536295
DOI: 10.1002/jcp.24906
PMCID: PMC6680109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Wild-type and specific mutant androgen receptor mediates transcription via 17β-estradiol in sex hormone-sensitive cancer cells.PMID 25536295Read ↗

Androgen receptor signaling and mutations in prostate cancer.Semantic proximity Read ↗

Deciphering Steroid Receptor Crosstalk in Hormone-Driven CancersSemantic proximity Read ↗

Role of steroid receptor and coregulator mutations in hormone-dependent cancers.Semantic proximity Read ↗

Nuclear Estrogen Receptors in Prostate Cancer: From Genes to FunctionSemantic proximity Read ↗

Isolation and characterization of androgen receptor mutant, AR(M749L), with hypersensitivity to 17-beta estradiol treatment.Semantic proximity Read ↗

5β-Dihydrotestosterone and mutant androgen receptor vulnerability in prostate cancerSemantic proximity Read ↗

Domains of the Human Androgen Receptor Involved in Steroid Binding, Transcriptional Activation, and Subcellular LocalizationSemantic proximity Read ↗

Unfaithfulness and promiscuity of a mutant androgen receptor in a hormone-refractory prostate cancer.Semantic proximity Read ↗

5β-Dihydrotestosterone reveals a mutant androgen receptor vulnerability in prostate cancerSemantic proximity Read ↗

Determinants of Receptor- and Tissue-Specific Actions in Androgen SignalingSemantic proximity Read ↗

Mutation of the androgen receptor causes oncogenic transformation of the prostate.Semantic proximity Read ↗

Targeting rapid action of sex steroid receptors in breast and prostate cancersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.