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Article

Selecting causal genes from genome-wide association studies via functionally coherent subnetworks.

Nature methods - 1 Feb 2015

Taşan Murat, Musso Gabriel, Hao Tong, Vidal Marc, MacRae Calum A, Roth Frederick P

Abstract excerpt

Genome-wide association (GWA) studies have linked thousands of loci to human diseases, but the causal genes and variants at these loci generally remain unknown. Although investigators typically focus on genes closest to the associated polymorphisms, the causal gene is often more distal. Reliance on published work to prioritize candidates is biased toward well-characterized genes. We describe a 'prix fixe'...

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PMID: 25532137
DOI: 10.1038/nmeth.3215
PMCID: PMC4480866

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