Article
Loss of Sirt1 promotes prostatic intraepithelial neoplasia, reduces mitophagy, and delays PARK2 translocation to mitochondria.
The American journal of pathology - 1 Jan 2015
Di Sante Gabriele, Pestell Timothy G, Casimiro Mathew C, Bisetto Sara, Powell Michael J, Lisanti Michael P, Cordon-Cardo Carlos, Castillo-Martin Mireia, Bonal Dennis M, Debattisti Valentina, Chen Ke, Wang Liping, He Xiaohong, McBurney Michael W, Pestell Richard G
Abstract excerpt
Prostatic intraepithelial neoplasia is a precursor to prostate cancer. Herein, deletion of the NAD(+)-dependent histone deacetylase Sirt1 induced histological features of prostatic intraepithelial neoplasia at 7 months of age; these features were associated with increased cell proliferation and enhanced mitophagy. In human prostate cancer, lower Sirt1 expression in the luminal epithelium was associated with poor...
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