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Article

Role of Sirtuin Histone Deacetylase SIRT1 in Prostate Cancer

16 Dec 2008

Abstract excerpt

Prostate cancer (PCa) is a major age-related malignancy, and according to estimates from the American Cancer Society, a man's chance of developing this cancer significantly increases with increasing age, from 1 in 10,149 by age 39 to 1 in 38 by age 59 to 1 in 7 by age 70. Therefore, it is important to identify the causal connection between mechanisms of aging and PCa. Employing in vitro and in vivo approaches, in...

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PMID: 19075016
DOI: 10.1074/jbc.m807869200

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