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Article

Dietary resveratrol prevents development of high-grade prostatic intraepithelial neoplastic lesions: involvement of SIRT1/S6K axis.

Cancer prevention research (Philadelphia, Pa.) - 1 Jan 2013

Li Guiming, Rivas Paul, Bedolla Roble, Thapa Dinesh, Reddick Robert L, Ghosh Rita, Kumar Addanki P

Abstract excerpt

SIRT1 (mammalian ortholog of the yeast silent information regulator 2) is a NAD-dependent histone deacetylase belonging to the multigene family of sirtuins. Anecdotal and epidemiologic observations provide evidence for beneficial effects of the calorie restriction mimetic resveratrol (RES), a SIRT1 activator in preventing cardiovascular diseases and cancer. Although SIRT1 possesses both tumorigenic and...

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Identifiers

PMID: 23248098
DOI: 10.1158/1940-6207.CAPR-12-0349
PMCID: PMC3536933

Genes

SIRT1
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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