Article
Aspirin-triggered lipoxin and resolvin E1 modulate vascular smooth muscle phenotype and correlate with peripheral atherosclerosis.
The American journal of pathology - 1 Oct 2010
Ho Karen J, Spite Matthew, Owens Christopher D, Lancero Hope, Kroemer Alex H K, Pande Reena, Creager Mark A, Serhan Charles N, Conte Michael S
Abstract excerpt
Atherosclerosis is a chronic inflammatory disease of the vessel wall. Recent evidence suggests that chronic vascular inflammation ensues as an imbalance between pro- and anti-inflammatory mediators. Recently identified lipid mediators (eg, lipoxins and resolvins) play active roles in promoting the resolution of inflammation. Alterations in vascular smooth muscle cell (VSMC) phenotype, which manifest as a loss of...
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