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Article

Annotation of genomics data using bidirectional hidden Markov models unveils variations in Pol II transcription cycle.

Molecular systems biology - 19 Dec 2014

Zacher Benedikt, Lidschreiber Michael, Cramer Patrick, Gagneur Julien, Tresch Achim

Abstract excerpt

DNA replication, transcription and repair involve the recruitment of protein complexes that change their composition as they progress along the genome in a directed or strand-specific manner. Chromatin immunoprecipitation in conjunction with hidden Markov models (HMMs) has been instrumental in understanding these processes, as they segment the genome into discrete states that can be related to DNA-associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25527639
DOI: 10.15252/msb.20145654
PMCID: PMC4300491

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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