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Article

Effect of APE1 T2197G (Asp148Glu) polymorphism on APE1, XRCC1, PARP1 and OGG1 expression in patients with colorectal cancer.

International journal of molecular sciences - 29 Sept 2014

Santos Juliana C, Funck Alexandre, Silva-Fernandes Isabelle J L, Rabenhorst Silvia H B, Martinez Carlos A R, Ribeiro Marcelo L

Abstract excerpt

It has been hypothesized that genetic variation in base excision repair (BER) might modify colorectal adenoma risk. Thus, we evaluated the influence of APE1 T2197G (Asp148Glu) polymorphism on APE1, XRCC1, PARP1 and OGG1 expression in normal and tumor samples from patients with colorectal cancer. The results indicate a downregulation of OGG1 and an upregulation of XRCC1 expression in tumor tissue. Regarding the...

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Identifiers

PMID: 25268610
DOI: 10.3390/ijms151017333
PMCID: PMC4227165

Genes

OGG1
XRCC1
PARP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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