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Article

Accelerated long-term forgetting is a BACE1 inhibitor-reversible incipient cognitive phenotype in Alzheimer's disease model mice.

Neuropsychopharmacology reports - 1 Jun 2021

Ohno Masuo

Abstract excerpt

AIM: After the continued failure of β-secretase (BACE1) inhibitor clinical trials in prodromal as well as mild-to-moderate Alzheimer's disease (AD), they are shifting to further earlier or asymptomatic stages. The aim of this study is to explore a cognitive paradigm that allows us to more sensitively detect beneficial effects of BACE1 inhibitors in presymptomatic AD. METHODS: GRL-8234 (33.4 mg/kg, ip), a...

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Identifiers

PMID: 33749160
DOI: 10.1002/npr2.12174
PMCID: PMC8340838

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