Article
Bacterial natural product biosynthetic domain composition in soil correlates with changes in latitude on a continent-wide scale.
Proceedings of the National Academy of Sciences of the United States of America - 31 Oct 2017
Lemetre Christophe, Maniko Jeffrey, Charlop-Powers Zachary, Sparrow Ben, Lowe Andrew J, Brady Sean F
Abstract excerpt
Although bacterial bioactive metabolites have been one of the most prolific sources of lead structures for the development of small-molecule therapeutics, very little is known about the environmental factors associated with changes in secondary metabolism across natural environments. Large-scale sequencing of environmental microbiomes has the potential to shed light on the richness of bacterial biosynthetic...
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