Article
Hb E/beta-thalassaemia: a common & clinically diverse disorder.
The Indian journal of medical research - 1 Oct 2011
Olivieri Nancy F, Pakbaz Zahra, Vichinsky Elliott
Abstract excerpt
Haemoglobin E-beta thalassaemia (Hb E/β-thalassaemia) is the genotype responsible for approximately one-half of all severe beta-thalassaemia worldwide. The disorder is characterized by marked clinical variability, ranging from a mild and asymptomatic anaemia to a life-threatening disorder requiring transfusions from infancy. The phenotypic variability of Hb E/β-thalassaemia and the paucity of long-term clinical...
Topics
- Blood Transfusion
- Erythropoietin
- Fetal Hemoglobin
- Genotype
- Hemoglobin E
- Humans
- Malaria
- Phenotype
- Polymorphism, Genetic
- Splenectomy
- alpha-Thalassemia
- beta-Thalassemia