HbE/β-thalassemia: basis of marked clinical diversity.

doi:10.1016/j.hoc.2010.08.008

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Article

HbE/β-thalassemia: basis of marked clinical diversity.

Hematology/oncology clinics of North America - 1 Dec 2010

Olivieri Nancy F, Pakbaz Zahra, Vichinsky Elliott

Abstract excerpt

Hemoglobin E thalassemia accounts for about one-half of all cases of severe beta thalassemia. There is marked variability in its clinical severity ranging from an asymptomatic to a transfusion-dependent phenotype. The phenotypic variability and inadequate longitudinal data present challenges in determining the optimal management of patients. This article summarizes findings on the natural history of Hemoglobin E...

Topics

Fetal Hemoglobin
Genetic Heterogeneity
Hemoglobin E
Humans
Mutation
Polymorphism, Genetic
alpha-Thalassemia
beta-Thalassemia

Source

Open in PubMed

Identifiers

PMID: 21075280
DOI: 10.1016/j.hoc.2010.08.008

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