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Sex differences in the genome-wide DNA methylation pattern and impact on gene expression, microRNA levels and insulin secretion in human pancreatic islets

3 Dec 2014

Abstract excerpt

BACKGROUND: Epigenetic factors regulate tissue-specific expression and X-chromosome inactivation. Previous studies have identified epigenetic differences between sexes in some human tissues. However, it is unclear whether epigenetic modifications contribute to sex-specific differences in insulin secretion and metabolism. Here, we investigate the impact of sex on the genome-wide DNA methylation pattern in human...

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Share to Epigenetics and DNA Methylation
Share to Genetic Associations and Epidemiology
Share to Pancreatic function and diabetes

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PMID: 25517766
DOI: 10.1186/s13059-014-0522-z

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