Article
[Genetics of ankylosing spondylitis].
Revista medica de Chile - 1 Sept 2014
Castro-Santos Patricia, Gutiérrez Miguel A, Díaz-Peña Roberto
Abstract excerpt
Ankylosing spondylitis (AS) is a prototypical inflammatory disease of the locomotor system affecting axial skeleton. It is part of the general group of spondyloarthopathies (SpA). Its strong association with histocompatibility antigen HLA-B27 is known since 1973. However, HLA-B27 contribution to AS genetic risk is approximately 16%. Therefore, other genes are necessarily involved in the pathogenesis of the...
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