Article
Low frequency of KRAS mutation in pancreatic ductal adenocarcinomas in Korean patients and its prognostic value.
Pancreas - 1 Apr 2015
Kwon Mi Jung, Jeon Jang Yong, Park Hye-Rim, Nam Eun Sook, Cho Seong Jin, Shin Hyung Sik, Kwon Ji Hyun, Kim Joo Seop, Han Boram, Kim Dong Hoon, Choi Yoon-La
Abstract excerpt
OBJECTIVES: Low prevalence and prognostic relevance of KRAS mutations in Korean pancreatic ductal adenocarcinomas (PDACs) need to be validated with sensitive detection method. METHODS: Peptide nucleic acid (PNA)-mediated polymerase chain reaction (PCR) clamping was used to precisely detect KRAS mutation in 72 paraffinized tumor samples and was validated by pancreatic cell lines to compare the efficiency of direct...
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