Article

Critical role of KRAS mutation in pancreatic ductal adenocarcinoma

2018-12-01

Abstract excerpt

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal human cancers worldwide. Little progress has been made in recent years concerning its diagnosis and treatment. Genetic alterations can be found in approximately 97% of PDAC cases. Mutations in the KRAS gene, which encodes the KRAS protein that regulates cell proliferation, differentiation, and apoptosis via activation of downstream signal...

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Literature Corpus work: fe0f5758-6735-5ca0-9561-0cdb2bba2838
DOI: 10.21037/tcr.2018.10.19

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