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Article

A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes.

Cancer cell - 14 Dec 2015

Giachino Claudio, Boulay Jean-Louis, Ivanek Robert, Alvarado Alvaro, Tostado Cristobal, Lugert Sebastian, Tchorz Jan, Coban Mustafa, Mariani Luigi, Bettler Bernhard, Lathia Justin, Frank Stephan, Pfister Stefan, Kool Marcel, Taylor Verdon

Abstract excerpt

In the brain, Notch signaling maintains normal neural stem cells, but also brain cancer stem cells, indicating an oncogenic role. Here, we identify an unexpected tumor suppressor function for Notch in forebrain tumor subtypes. Genetic inactivation of RBP-Jκ, a key Notch mediator, or Notch1 and Notch2 receptors accelerates PDGF-driven glioma growth in mice. Conversely, genetic activation of the Notch pathway...

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Identifiers

PMID: 26669487
DOI: 10.1016/j.ccell.2015.10.008

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