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Article

Detection of Tumor Suppressor Genes Rare Variants: Findings From Neuroblastoma Using Next-Generation Sequencing.

Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society - 1 Jan 2026

Erol Aylin, Kızmazoğlu Deniz, Aktaş Tekincan Çağrı, Elif Gökbayrak Özde, Aktaş Safiye

Abstract excerpt

BACKGROUND/OBJECTIVES: Neuroblastomas (NB) influenced by genetic alterations, which plays significant role in disease progression. Tumor suppressor genes (TSGs) are crucial in regulating cell growth, suppressing replication, and inducing apoptosis to prevent cancer formation. However, mutations in TSGs can lead to loss of normal activity, contributing to cancer development. This study aimed to identify TSG...

Read the complete abstract on PubMed

Topics

Humans
High-Throughput Nucleotide Sequencing
Female
Genes, Tumor Suppressor
Neuroblastoma

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Male

Infant

Child, Preschool

Mutation

Child

Biomarkers, Tumor

Genetic Predisposition to Disease

DNA Mutational Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 42057469
DOI: 10.1177/10935266251413938
PMCID: PMC13558810

Genes

ATM
PTEN
RB1
TP53

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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